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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6061
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pubmed:dateCreated |
1986-5-7
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pubmed:databankReference |
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pubmed:abstractText |
A new acute transforming feline retrovirus, the Hardy-Zuckerman 4 feline sarcoma virus (HZ4-FeSV), has been isolated from a feline fibrosarcoma. The viral genome of HZ4-FeSV contains a new oncogene designated v-kit, has the structure 5' delta gag-kit-delta pol-delta env 3' and specifies a gag-kit polyprotein of relative molecular mass 80,000. The predicted kit amino-acid sequence displays partial homology with tyrosine-specific protein kinase oncogenes. HZ4-FeSV appears to have been generated by transduction of feline c-kit sequences with feline leukaemia virus.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
320
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
415-21
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:3007997-Amino Acid Sequence,
pubmed-meshheading:3007997-Base Sequence,
pubmed-meshheading:3007997-Cell Transformation, Viral,
pubmed-meshheading:3007997-Gene Products, gag,
pubmed-meshheading:3007997-Genes,
pubmed-meshheading:3007997-Molecular Weight,
pubmed-meshheading:3007997-Oncogene Proteins, Viral,
pubmed-meshheading:3007997-Oncogenes,
pubmed-meshheading:3007997-Protein Kinases,
pubmed-meshheading:3007997-Proto-Oncogenes,
pubmed-meshheading:3007997-Recombination, Genetic,
pubmed-meshheading:3007997-Retroviridae,
pubmed-meshheading:3007997-Retroviridae Proteins,
pubmed-meshheading:3007997-Sarcoma Viruses, Feline
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pubmed:articleTitle |
A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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