Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1986-5-5
pubmed:abstractText
A retrospective study was conducted to determine whether exposure to murine mammary tumor virus (MuMTV) induced MuMTV-specific serologic responses among intramural laboratory personnel. Results obtained with a panel of five purified structural proteins of the RIII mouse strain milk-derived MuMTV (gp55, gp34, p28, p18, and p12), by means of the enzyme-linked immunosorbent assay to assess antibody binding, established that MuMTV exposure resulted in highly significant increases in serologic responses to these test antigens as compared to age- and gender-matched controls without overt contact with MuMTV. Furthermore, immunoreactions to gp55 and gp34 were found not to be directed to the carbohydrate moieties of these glycoproteins. Similar results were obtained by assays of human immunoglobulin binding to Western blots of MuMTV proteins. These increased MuMTV-specific immunoreactivities, in general, were found to be related to degree and length of exposure to this virus. These results with MuMTV suggest the possibility of important human immune response differences between exposure to type B (MuMTV) and animal type C (leukemia-sarcoma) RNA tumor viruses, perhaps reflective of sensitivity to antibody dependence of complement-induced virolysis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0027-8874
pubmed:author
pubmed:issnType
Print
pubmed:volume
76
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
611-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:3007844-Adolescent, pubmed-meshheading:3007844-Adult, pubmed-meshheading:3007844-Age Factors, pubmed-meshheading:3007844-Aged, pubmed-meshheading:3007844-Animals, pubmed-meshheading:3007844-Antibodies, Viral, pubmed-meshheading:3007844-Deltaretrovirus, pubmed-meshheading:3007844-Environmental Exposure, pubmed-meshheading:3007844-Female, pubmed-meshheading:3007844-Glycoproteins, pubmed-meshheading:3007844-Humans, pubmed-meshheading:3007844-Immunoglobulin G, pubmed-meshheading:3007844-Laboratories, pubmed-meshheading:3007844-Male, pubmed-meshheading:3007844-Mammary Tumor Virus, Mouse, pubmed-meshheading:3007844-Mice, pubmed-meshheading:3007844-Middle Aged, pubmed-meshheading:3007844-Milk Proteins, pubmed-meshheading:3007844-Retroviridae Proteins, pubmed-meshheading:3007844-Sex Factors
pubmed:year
1986
pubmed:articleTitle
Serologic responses to murine mammary tumor virus (MuMTV) in MuMTV-exposed laboratory personnel.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.