Linked Life Data

3007586

Source:http://linkedlifedata.com/resource/pubmed/id/3007586

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-5-22
pubmed:abstractText
Cytochrome oxidase histochemistry was used to examine the effects of visual deprivation on the development of neurons in the lateral geniculate nucleus of the kitten. Early postnatal monocular suture results in a decrease in reactivity within the neuropil of visually deprived binocular laminae A, A1, magnocellular C, and medial interlaminar nucleus. Within these regions, monocular suture has a greater effect on the relative numbers of, and the growth of darkly reactive (normally large), presumed Y-cells than on other less reactive geniculate neuronal classes. The decreases in the reactivity of the neuropil may be attributed to the decreases in the number of mitochondria, the number of darkly reactive mitochondria, and/or the number of darkly reactive mitochondria localized within dendrites. Although all classes of dendrites appear to be adversely affected, the decrease in C.O. reactivity was most dramatic within the presumed proximal dendrites of class 1 Y-cells. These dendrites were identified by the type of synaptic contacts they formed with retinal terminals (Rapisardi and Miles, '84, J. Comp. Neurol. 223:515-534; Wilson et al., '84, Proc. R. Soc. Lond. [Biol.] 221:411-436). As with Y-cells, the effects of monocular suture on the large darkly reactive cells were not as dramatic at sites where binocular interactions were either absent or where they had been experimentally eliminated. Based on the present and previously reported findings from several laboratories, it is likely that the selective physiological and morphological effects of monocular suture on Y-cells are accompanied by metabolic deficits involving both dendrites and perikarya. These effects appear to be due more to binocular interactions than to visual deprivation per se.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0021-9967
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
246
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
212-37
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Differential effect of visual deprivation on cytochrome oxidase levels in major cell classes of the cat LGN.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.