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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1986-5-14
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pubmed:abstractText |
Experimental results and theoretical considerations on the biology of alcoholism are devoted to the following topics: genetically determined differences in metabolic tolerance; participation of the alternative alcohol metabolizing systems in chronic alcohol intake; genetically determined differences in functional tolerance of the CNS to the hypnotic effect of alcohol; cross tolerance between alcohol and centrally active drugs; dissociation of tolerance and cross tolerance from physical dependence; permanent effect of uncontrolled drinking behavior induced by alkaloid metabolites in the CNS; genetically determined alterations in the function of opiate receptors; and genetic predisposition to addiction due to innate endorphin deficiency. For the purpose of introducing the most important research teams and their main work, statements from selected publications of individual groups have been classified as to subject matter and summarized. Although the number for summary-quotations had to be restricted, the criterion for selection was the relevance to the etiology of alcoholism rather than consequences of alcohol drinking.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetaldehyde,
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Adenylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Alkaloids,
http://linkedlifedata.com/resource/pubmed/chemical/Arginine Vasopressin,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Carbolines,
http://linkedlifedata.com/resource/pubmed/chemical/Catecholamines,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 Enzyme System,
http://linkedlifedata.com/resource/pubmed/chemical/Endorphins,
http://linkedlifedata.com/resource/pubmed/chemical/Ethanol,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxydopamines,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Isoquinolines,
http://linkedlifedata.com/resource/pubmed/chemical/Lypressin,
http://linkedlifedata.com/resource/pubmed/chemical/Morphine,
http://linkedlifedata.com/resource/pubmed/chemical/NADP,
http://linkedlifedata.com/resource/pubmed/chemical/Narcotic Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidopamine,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium-Potassium-Exchanging ATPase,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrahydropapaveroline,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid,
http://linkedlifedata.com/resource/pubmed/chemical/tryptoline,
http://linkedlifedata.com/resource/pubmed/chemical/vasopressin, 9-des-Gly-NH(2)-Lys-
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pubmed:status |
MEDLINE
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pubmed:issn |
0741-8329
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
711-88
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:3006723-Acetaldehyde,
pubmed-meshheading:3006723-Acetylcholine,
pubmed-meshheading:3006723-Adaptation, Physiological,
pubmed-meshheading:3006723-Adenylate Cyclase,
pubmed-meshheading:3006723-Alcoholism,
pubmed-meshheading:3006723-Alkaloids,
pubmed-meshheading:3006723-Animals,
pubmed-meshheading:3006723-Arginine Vasopressin,
pubmed-meshheading:3006723-Brain,
pubmed-meshheading:3006723-Calcium,
pubmed-meshheading:3006723-Carbohydrate Metabolism,
pubmed-meshheading:3006723-Carbolines,
pubmed-meshheading:3006723-Catecholamines,
pubmed-meshheading:3006723-Cell Membrane,
pubmed-meshheading:3006723-Cytochrome P-450 Enzyme System,
pubmed-meshheading:3006723-Disease Models, Animal,
pubmed-meshheading:3006723-Dose-Response Relationship, Drug,
pubmed-meshheading:3006723-Drug Interactions,
pubmed-meshheading:3006723-Drug Tolerance,
pubmed-meshheading:3006723-Endorphins,
pubmed-meshheading:3006723-Energy Metabolism,
pubmed-meshheading:3006723-Ethanol,
pubmed-meshheading:3006723-Female,
pubmed-meshheading:3006723-Humans,
pubmed-meshheading:3006723-Hydroxydopamines,
pubmed-meshheading:3006723-Isoenzymes,
pubmed-meshheading:3006723-Isoquinolines,
pubmed-meshheading:3006723-Liver,
pubmed-meshheading:3006723-Lypressin,
pubmed-meshheading:3006723-Male,
pubmed-meshheading:3006723-Mice,
pubmed-meshheading:3006723-Microsomes,
pubmed-meshheading:3006723-Morphine,
pubmed-meshheading:3006723-NADP,
pubmed-meshheading:3006723-Narcotic Antagonists,
pubmed-meshheading:3006723-Oxidation-Reduction,
pubmed-meshheading:3006723-Oxidopamine,
pubmed-meshheading:3006723-Oxygen Consumption,
pubmed-meshheading:3006723-Phenotype,
pubmed-meshheading:3006723-Rats,
pubmed-meshheading:3006723-Saccharin,
pubmed-meshheading:3006723-Serotonin,
pubmed-meshheading:3006723-Sodium-Potassium-Exchanging ATPase,
pubmed-meshheading:3006723-Species Specificity,
pubmed-meshheading:3006723-Structure-Activity Relationship,
pubmed-meshheading:3006723-Tetrahydropapaveroline,
pubmed-meshheading:3006723-gamma-Aminobutyric Acid
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pubmed:articleTitle |
Biochemical basis of alcoholism: statements and hypotheses of present research.
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pubmed:publicationType |
Journal Article,
Review
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