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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1986-4-24
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pubmed:abstractText |
The chromosomal locations of the genes for the beta subunit of human thyroid-stimulating hormone (TSH) and the glycoprotein hormone alpha subunit have been determined by restriction enzyme analysis of DNA extracted from rodent-human somatic cell hybrids. Human chorionic gonadotropin (CG) alpha-subunit cDNA and a cloned 0.9-kilobase (kb) fragment of the human TSH beta-subunit gene were used as hybridization probes in the analysis of Southern blots of DNA extracted from rodent-human hybrid clones. Analysis of the segregation of 5- and 10-kb EcoRI fragments hybridizing to CG alpha-subunit cDNA confirmed the previous assignment of this gene to chromosome 6. Analysis of the patterns of segregation of a 2.3-kb EcoRI fragment containing human TSH beta-subunit sequences permitted the assignment of the TSH beta-subunit gene to human chromosome 1. The subregional assignment of TSH beta subunit to chromosome 1p22 was made possible by the additional analysis of a set of hybrids containing partially overlapping segments of this chromosome. Human TSH beta subunit is not syntenic with genes encoding the beta subunits of CG, luteinizing hormone, or follicle-stimulating hormone and is assigned to a conserved linkage group that also contains the structural genes for the beta subunit of nerve growth factor (NGFB) and the proto-oncogene N-ras (NRAS).
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-2578949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-2578951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-2865325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-3456173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-4042813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-441732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-481597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-531732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6089108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6093508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6193112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6194155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6194981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6196780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6201859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6203727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-62055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6206575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6207569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6209808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6262319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6267989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6286817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6300838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6306659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6314263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6319099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6325416,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6360563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6572965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6578509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6581542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6582507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6585973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6593709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6688123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6690982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6801664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-6972865,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-7242260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-881736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3006075-890569
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
83
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1822-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3006075-Humans,
pubmed-meshheading:3006075-Animals,
pubmed-meshheading:3006075-Mice,
pubmed-meshheading:3006075-Cattle,
pubmed-meshheading:3006075-Thyrotropin,
pubmed-meshheading:3006075-DNA,
pubmed-meshheading:3006075-Cricetinae,
pubmed-meshheading:3006075-Melanoma,
pubmed-meshheading:3006075-Fibroblasts,
pubmed-meshheading:3006075-Chorionic Gonadotropin,
pubmed-meshheading:3006075-Chromosome Mapping,
pubmed-meshheading:3006075-L Cells (Cell Line),
pubmed-meshheading:3006075-Cricetulus,
pubmed-meshheading:3006075-Cell Line,
pubmed-meshheading:3006075-Chromosomes, Human, 1-3,
pubmed-meshheading:3006075-Hybrid Cells,
pubmed-meshheading:3006075-Genetic Markers
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