Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1986-4-4
|
pubmed:abstractText |
We examined the effect of thyrotropin (TSH) on intracellular levels of c-ras mRNA in a line of differentiated rat thyroid cells obtained from normal Fischer rat thyroids. These cells are totally dependent on TSH for growth. TSH stimulation of quiescent cells increased c-ras mRNA content, with a maximal response (730% of basal) after 6 h, and a decline towards basal levels after 24 h. Dibutyryl cAMP and forskolin mimicked this stimulatory effect of TSH on c-ras, but did not enhance beta-actin mRNA content. This study demonstrates hormonal and cyclic nucleotide control of c-ras expression in a well-differentiated, non-tumorogenic mammalian cell.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0014-5793
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
17
|
pubmed:volume |
196
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
305-8
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:3005036-Animals,
pubmed-meshheading:3005036-Cell Differentiation,
pubmed-meshheading:3005036-Cell Division,
pubmed-meshheading:3005036-Cells, Cultured,
pubmed-meshheading:3005036-Cyclic AMP,
pubmed-meshheading:3005036-Gene Expression Regulation,
pubmed-meshheading:3005036-Proto-Oncogenes,
pubmed-meshheading:3005036-Rats,
pubmed-meshheading:3005036-Thyroid Gland,
pubmed-meshheading:3005036-Thyrotropin
|
pubmed:year |
1986
|
pubmed:articleTitle |
Thyrotropin and cyclic AMP regulation of ras proto-oncogene expression in cultured thyroid cells.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|