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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1986-4-23
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pubmed:databankReference |
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pubmed:abstractText |
cDNA clones coding for human S-protein have been isolated using monoclonal antibodies to screen a cDNA library in pEX. These clones are shown to be authentic S-protein clones on the basis of sequence, composition and immunological criteria. The complete open reading frame sequence for S-protein has been determined and shows it to be a single polypeptide chain of 459 amino acids preceded by a cleaved leader peptide of 19 residues. No evidence was found for polymorphism of S-protein suggesting that different molecular weight forms arise by proteolytic degradation. Of the first 44 amino-terminal residues 42 are identical with the so-called somatomedin B peptide suggesting that S-protein is the somatomedin B precursor. Striking homology is found in the rest of the sequence with the serum spreading factor, vitronectin, which has also been shown to contain somatomedin B sequences at its amino terminus. We conclude that S-protein and vitronectin are identical and discuss the relevance of this finding to the coagulation and complement pathways.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-1002985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-10976223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-115783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-2581612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-2581980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-327557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-3886996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-3896119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-3897036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-4000197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-4018030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-4027354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-4062902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-410885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-4451569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-4542208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-47885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-6086324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-6128348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-6163926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-6166677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-6183580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-6187012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-6191278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-6191326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-6199029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-6210287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-631332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-6325925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-6348093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-6587746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-6630199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-6801180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-6957884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-6973821,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-6988507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-7130282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3004934-7142286
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3153-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3004934-Amino Acid Sequence,
pubmed-meshheading:3004934-Amino Acids,
pubmed-meshheading:3004934-Antibodies, Monoclonal,
pubmed-meshheading:3004934-Base Sequence,
pubmed-meshheading:3004934-Cloning, Molecular,
pubmed-meshheading:3004934-Complement System Proteins,
pubmed-meshheading:3004934-DNA,
pubmed-meshheading:3004934-DNA Restriction Enzymes,
pubmed-meshheading:3004934-Genes,
pubmed-meshheading:3004934-Glycoproteins,
pubmed-meshheading:3004934-Humans,
pubmed-meshheading:3004934-Liver,
pubmed-meshheading:3004934-Membrane Glycoproteins,
pubmed-meshheading:3004934-Protein Binding
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pubmed:year |
1985
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pubmed:articleTitle |
Molecular cloning of S-protein, a link between complement, coagulation and cell-substrate adhesion.
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pubmed:publicationType |
Journal Article
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