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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1986-2-24
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pubmed:abstractText |
A comprehensive nationwide surveillance program of serologic immunity of two-year-old black children, combined with evaluation of vaccine quality and distribution, was carried out in South Africa during 1983-1984. Sera were randomly collected from urban and rural groups and cluster samples collected from the semi-urban group. The sample represented 0.23% of the total target population. Satisfactory levels of immunity were found in the urban (80%) and semi-urban (71%) groups but a disquietingly low level was found for the rural group (59%). Individual districts in the rural group could be singled out for directed cluster sampling at a later stage. History and documentation of immunization corresponded well to serologic findings and revealed also a fairly substantial level of natural immunization among individuals who, on history, had received no vaccine. Some 95% of random samples of vaccine recalled from the field showed satisfactory levels of potency. An immunity surveillance program such as this is ideally suited and highly cost-effective for developing countries with incomplete immunization to prevent large-scale buildup of immunity deficit. The technique, however, is too insensitive to detect localized community immunity defects.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
|
pubmed:issn |
0002-9262
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
123
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
316-24
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3004199-Antibodies, Viral,
pubmed-meshheading:3004199-Child, Preschool,
pubmed-meshheading:3004199-Data Collection,
pubmed-meshheading:3004199-Developing Countries,
pubmed-meshheading:3004199-Epidemiologic Methods,
pubmed-meshheading:3004199-Humans,
pubmed-meshheading:3004199-Neutralization Tests,
pubmed-meshheading:3004199-Poliomyelitis,
pubmed-meshheading:3004199-Poliovirus,
pubmed-meshheading:3004199-Poliovirus Vaccine, Inactivated,
pubmed-meshheading:3004199-Random Allocation,
pubmed-meshheading:3004199-Rural Population,
pubmed-meshheading:3004199-South Africa,
pubmed-meshheading:3004199-Urban Population
|
pubmed:year |
1986
|
pubmed:articleTitle |
A comprehensive investigation of immunity to poliomyelitis in a developing country.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|