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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1986-2-26
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pubmed:abstractText |
The unilateral microinjection of ACTH 1-24 (20 nmol) into the locus coeruleus (LC) produced a long lasting (2-3 hr) posture asymmetry and movement disorder in all rats tested. This response was readily suppressed by the subsequent local microinjection of an equimolar dose of beta-endorphin or morphine or by the intraperitoneal injection of morphine sulphate (50 mg/kg). Microinjection of naloxone (20 nmol) into the LC produced the above syndrome in a lower percentage of animals. The results support the hypothesis that ACTH peptides and opioids play opposite roles in the control of different brain functions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0024-3205
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
373-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3003478-Adrenocorticotropic Hormone,
pubmed-meshheading:3003478-Animals,
pubmed-meshheading:3003478-Cosyntropin,
pubmed-meshheading:3003478-Dyskinesia, Drug-Induced,
pubmed-meshheading:3003478-Endorphins,
pubmed-meshheading:3003478-Locus Coeruleus,
pubmed-meshheading:3003478-Male,
pubmed-meshheading:3003478-Microinjections,
pubmed-meshheading:3003478-Morphine,
pubmed-meshheading:3003478-Naloxone,
pubmed-meshheading:3003478-Posture,
pubmed-meshheading:3003478-Rats,
pubmed-meshheading:3003478-Rats, Inbred Strains,
pubmed-meshheading:3003478-beta-Endorphin
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pubmed:year |
1986
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pubmed:articleTitle |
Morphine and beta-endorphin antagonize posture and locomotor disorders induced by the injection of ACTH 1-24 in the rat locus coeruleus.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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