|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0002518,
umls-concept:C0004793,
umls-concept:C0019822,
umls-concept:C0030389,
umls-concept:C0033684,
umls-concept:C0035696,
umls-concept:C0042776,
umls-concept:C0086418,
umls-concept:C0332307,
umls-concept:C0439801,
umls-concept:C1998793
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1986-2-28
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
The nucleotide sequence of mRNA for the hemagglutinin-neuraminidase (HN) protein of human parainfluenza type 3 virus obtained from the corresponding cDNA clone had a single long open reading frame encoding a putative protein of 64,254 daltons consisting of 572 amino acids. The deduced protein sequence was confirmed by limited N-terminal amino acid microsequencing of CNBr cleavage fragments of native HN that was purified by immunoprecipitation. The HN protein is moderately hydrophobic and has four potential sites (Asn-X-Ser/Thr) of N-glycosylation in the C-terminal half of the molecule. It is devoid of both the N-terminal signal sequence and the C-terminal membrane anchorage domain characteristic of the hemagglutinin of influenza virus and the fusion (F0) protein of the paramyxoviruses. Instead, it has a single prominent hydrophobic region capable of membrane insertion beginning at 32 residues from the N terminus. This N-terminal membrane insertion is similar to that of influenza virus neuraminidase and the recently reported structures of HN proteins of Sendai virus and simian virus 5.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-13367330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-195398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-2414910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-2981971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-2986845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-2987519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-2987829,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-2993658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-2998013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-3973974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-4118317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-4504350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-467674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-489565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-5101090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-6092708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-6093114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-6096854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-6154871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-6166921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-6178797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-6188957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-6192203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-6193632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-6243200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-6254036,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-6270242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-6281335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-6316257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-6317203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-6343759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-6351727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-642007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-6534031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-6572363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-6572388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-6929499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-6994202,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-7010182,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-7072153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-7108955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-726267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-729783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-7463006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-7467135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003381-911786
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/HN Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Hemagglutinins, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Neuraminidase,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Envelope Proteins
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0022-538X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
57
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
481-9
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:3003381-Peptide Fragments,
pubmed-meshheading:3003381-Molecular Weight,
pubmed-meshheading:3003381-Glycoproteins,
pubmed-meshheading:3003381-Base Sequence,
pubmed-meshheading:3003381-RNA, Viral,
pubmed-meshheading:3003381-RNA, Messenger,
pubmed-meshheading:3003381-Neuraminidase,
pubmed-meshheading:3003381-Amino Acid Sequence,
pubmed-meshheading:3003381-Solubility,
pubmed-meshheading:3003381-Respirovirus,
pubmed-meshheading:3003381-Hemagglutinins, Viral,
pubmed-meshheading:3003381-Parainfluenza Virus 3, Human,
pubmed-meshheading:3003381-Cloning, Molecular
|
