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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1986-3-26
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pubmed:abstractText |
The pathogenesis and progression of rheumatoid arthritis involves the production of biologically active lymphokines and monokines. Of these, interleukin 1 (IL-1) has been somewhat of a controversial molecule because it seems to evoke various biological responses in several different tissues. In these studies we demonstrate that three biological properties of human monocyte-derived IL-1 (T-lymphocyte activation and human synovial cell prostaglandin E2 and collagenase production) co-purify. The complementary DNA for the prominent pI 7 form of human IL-1 was expressed, purified, and tested. Any controversy now appears resolved since homogeneous recombinant human IL-1 stimulates prostaglandin E2 and collagenase from human synovial cells as well as activates T cells in vitro.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003163-22079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003163-227933,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003163-3920526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003163-6092094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003163-6209582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003163-6235287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003163-6262122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003163-6264478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003163-6332129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003163-6395411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003163-6611312,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3003163-6805324
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
645-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3003163-Animals,
pubmed-meshheading:3003163-Arthritis, Rheumatoid,
pubmed-meshheading:3003163-Cells, Cultured,
pubmed-meshheading:3003163-Chromatography,
pubmed-meshheading:3003163-DNA, Recombinant,
pubmed-meshheading:3003163-Dinoprostone,
pubmed-meshheading:3003163-Escherichia coli,
pubmed-meshheading:3003163-Humans,
pubmed-meshheading:3003163-Interleukin-1,
pubmed-meshheading:3003163-Lymphocyte Activation,
pubmed-meshheading:3003163-Mice,
pubmed-meshheading:3003163-Mice, Inbred C3H,
pubmed-meshheading:3003163-Microbial Collagenase,
pubmed-meshheading:3003163-Monocytes,
pubmed-meshheading:3003163-Prostaglandins E,
pubmed-meshheading:3003163-Recombinant Proteins,
pubmed-meshheading:3003163-Synovial Membrane
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pubmed:year |
1986
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pubmed:articleTitle |
Human recombinant interleukin 1 stimulates collagenase and prostaglandin E2 production by human synovial cells.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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