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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1986-3-13
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pubmed:abstractText |
A monoclonal antibody specific for glycoprotein D (gD) of herpes simplex virus type 1 (HSV-1) was used to prepare an anti-idiotypic antibody in rabbits. After removal of antibody reactivity to constant region determinants by absorption with polyclonal mouse immunoglobulins and a monoclonal antibody of the same subclass as the anti-gD monoclonal, the anti-idiotypic (anti-id) antibody reacted specifically with anti-gD. Using an ELISA inhibition assay with immunoaffinity-purified gD, the anti-id D reagent inhibited the binding of anti-gD to gD, suggesting that anti-id D mimics an epitope of gD by binding the antigen-combining site of anti-gD. Immunization of mice with anti-id D could prime splenocytes in vivo to proliferate in response to HSV antigen stimulation in vitro. The possibility that anti-id D could act similarly to gD and stimulate an immune response to HSV when administered in vivo is discussed.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3002969-1172191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3002969-166500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3002969-2578680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3002969-4142565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3002969-4367302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3002969-6183357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3002969-6185584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3002969-6187827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3002969-6196105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3002969-6197535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3002969-6198721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3002969-6202879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3002969-6244225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3002969-6252346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3002969-6271681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3002969-6284965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3002969-6290390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3002969-6302707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3002969-6318433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3002969-6412379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3002969-6605428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3002969-88500
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
29-35
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:3002969-Animals,
pubmed-meshheading:3002969-Antibodies, Monoclonal,
pubmed-meshheading:3002969-Antibody Specificity,
pubmed-meshheading:3002969-Binding, Competitive,
pubmed-meshheading:3002969-Binding Sites, Antibody,
pubmed-meshheading:3002969-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:3002969-Female,
pubmed-meshheading:3002969-Humans,
pubmed-meshheading:3002969-Immunoglobulin Idiotypes,
pubmed-meshheading:3002969-Lymphocytes,
pubmed-meshheading:3002969-Mice,
pubmed-meshheading:3002969-Mice, Inbred BALB C,
pubmed-meshheading:3002969-Rabbits,
pubmed-meshheading:3002969-Simplexvirus,
pubmed-meshheading:3002969-Viral Envelope Proteins,
pubmed-meshheading:3002969-Viral Proteins
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pubmed:year |
1986
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pubmed:articleTitle |
Production and characterization of an anti-idiotypic antibody specific for a monoclonal antibody to glycoprotein D of herpes simplex virus.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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