|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1986-2-24
|
|
pubmed:abstractText |
The distribution of the conventional lymphoid cell markers on T lymphocytes and the principal panels of monoclonal antibodies used to recognize distinctive T-lymphocyte-associated differentiation antigens are discussed. These reagents have been used to probe the early and late stages of T-cell differentiation, and a hypothetical schema of T-cell differentiation has been constructed. Application of these reagents to the investigation of neoplastic T cells has resulted in the determination of the subset of origin and the stage of differentiation of the neoplastic cells in T-cell-derived lymphoproliferative malignancies. Recent advances in molecular biology have made possible the Southern blot hybridization analysis of DNA extracted from neoplastic T cells for patterns of T-cell-receptor gene rearrangements. Examination of these patterns in benign and malignant T and non-T cell has provided the basis for the use of T-cell-receptor gene rearrangements as specific genetic markers of T-cell lineage, clonality, and differentiation. These and other advances have resulted in the delineation of a new category of T-cell neoplasia, the adult T-cell leukemia/lymphoma syndrome. They have also demonstrated that the majority of clinically indolent neoplasms composed of large granular lymphocytes in so-called T gamma-lymphoproliferative disease are monoclonal proliferations. Further phenotypic, functional, and genotypic analyses of the T-cell malignancies should provide better understanding of T-lymphocyte differentiation and heterogeneity. Such studies should also lead to better clinicopathologic correlations and greater understanding of the basis for the clinical diversity of the T-cell-derived lymphoproliferative malignancies.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Restriction Enzymes,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0046-8177
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
17
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
14-33
|
|
pubmed:dateRevised |
2007-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:3002948-Adult,
pubmed-meshheading:3002948-Aged,
pubmed-meshheading:3002948-Antibodies, Monoclonal,
pubmed-meshheading:3002948-Antigens,
pubmed-meshheading:3002948-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:3002948-Antigens, Surface,
pubmed-meshheading:3002948-Atlantic Islands,
pubmed-meshheading:3002948-B-Lymphocytes,
pubmed-meshheading:3002948-Cell Differentiation,
pubmed-meshheading:3002948-Cell Nucleus,
pubmed-meshheading:3002948-Child,
pubmed-meshheading:3002948-Child, Preschool,
pubmed-meshheading:3002948-Clone Cells,
pubmed-meshheading:3002948-Cytoplasm,
pubmed-meshheading:3002948-DNA,
pubmed-meshheading:3002948-DNA Restriction Enzymes,
pubmed-meshheading:3002948-Deltaretrovirus,
pubmed-meshheading:3002948-Female,
pubmed-meshheading:3002948-Genotype,
pubmed-meshheading:3002948-HLA-DR Antigens,
pubmed-meshheading:3002948-Histocompatibility Antigens Class II,
pubmed-meshheading:3002948-Histocytochemistry,
pubmed-meshheading:3002948-Humans,
pubmed-meshheading:3002948-Immunoglobulins,
pubmed-meshheading:3002948-Japan,
pubmed-meshheading:3002948-Leukemia, Lymphoid,
pubmed-meshheading:3002948-Leukocyte Count,
pubmed-meshheading:3002948-Lymphoproliferative Disorders,
pubmed-meshheading:3002948-Male,
pubmed-meshheading:3002948-Middle Aged,
pubmed-meshheading:3002948-Nucleic Acid Hybridization,
pubmed-meshheading:3002948-Phenotype,
pubmed-meshheading:3002948-Prognosis,
pubmed-meshheading:3002948-Receptors, Immunologic,
pubmed-meshheading:3002948-Retroviridae Infections,
pubmed-meshheading:3002948-Rosette Formation,
pubmed-meshheading:3002948-Sex Factors,
pubmed-meshheading:3002948-T-Lymphocytes,
pubmed-meshheading:3002948-T-Lymphocytes, Helper-Inducer,
pubmed-meshheading:3002948-T-Lymphocytes, Regulatory,
pubmed-meshheading:3002948-United States
|
|
pubmed:year |
1986
|
|
pubmed:articleTitle |
The human T-cell leukemias: clinical, cytomorphologic, immunophenotypic, and genotypic characteristics.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Review,
Research Support, Non-U.S. Gov't
|
