|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
1986-3-26
|
|
pubmed:abstractText |
Membrane proteins have been isolated from neuromuscular synapses of the crab Potamon transcaspicum using a specific blocker of glutamatergic synapses, the neurotoxin of the spider Argiope lobata. These membrane components have been shown to induce glutamate-sensitive conductance in bilayer lipid membranes (BLM) in the presence of sodium ions. As an agent blocking desensitization of glutamatergic synapses, concanavalin A was shown to enhance the conductance and to abolish desensitization. Diethylester of glutamic acid as a blocker of glutamatergic synapses inhibited glutamate-induced conductance. No similar change in conductance was seen when BLM was modified by a membrane proteins -neurotoxin complex. Conductance current fluctuations induced by these receptor protein components were monitored by the single-channel registration method.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0231-5882
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
4
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
625-30
|
|
pubmed:dateRevised |
2003-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:3002906-Animals,
pubmed-meshheading:3002906-Arthropod Venoms,
pubmed-meshheading:3002906-Brachyura,
pubmed-meshheading:3002906-Concanavalin A,
pubmed-meshheading:3002906-Electric Conductivity,
pubmed-meshheading:3002906-Glutamates,
pubmed-meshheading:3002906-Kinetics,
pubmed-meshheading:3002906-Lipid Bilayers,
pubmed-meshheading:3002906-Receptors, Glutamate,
pubmed-meshheading:3002906-Receptors, Neurotransmitter,
pubmed-meshheading:3002906-Spider Venoms
|
|
pubmed:year |
1985
|
|
pubmed:articleTitle |
Reconstitution in bilayer lipid membranes of the crab Potamon transcaspicum spider venom sensitive glutamate receptors.
|
|
pubmed:publicationType |
Journal Article
|
