Linked Life Data

3002754

Source:http://linkedlifedata.com/resource/pubmed/id/3002754

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1986-3-5
pubmed:abstractText
The shape of rat myometrial cells in culture was altered by exposure to hormones. Oxytocin (107 microU/ml) significantly decreased mean cell length and area. Treatment of oxytocin-treated cells with relaxin (1.5 micrograms/ml), isoproterenol (10 microM) or (Bu)2 cAMP (1 mM) for 15 min resulted in a significant increase in cell length and area. The effect of relaxin was time dependent, with a significant increase in cell length by 1 min and in cell area by 3 min. Relaxin elicited a concentration-dependent increase in cell length and area between 0.1 and 2 micrograms/ml. The actions of relaxin correlate in time course and concentration dependence with its effects on cAMP elevation in the presence of 0.4 microM forskolin and on changes in myosin light chain kinase kinetic parameters in these cells. Myometrial cells in culture constitute a useful model system in which to correlate physical and biochemical effects of relaxin and other hormones.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0013-7227
pubmed:author
pubmed:issnType
Print
pubmed:volume
118
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
495-8
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Relaxin affects the shape of rat myometrial cells in culture.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.