|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1986-2-28
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|
pubmed:abstractText |
A recently developed radioimmunoassay for direct measurement of 18-hydroxycortisol (18-OH-F) in plasma and urine has been used to study the physiology of this newly described steroid in normal subjects. Plasma levels of 18-OH-F show a circadian variation similar to that of cortisol and are increased and suppressed by administration of ACTH and dexamethasone respectively. A clear increase was observed in response to sodium restriction but despite this, angiotensin II infusion failed to cause a rise in 18-OH-F levels and a possible explanation is discussed. The results are interpreted in terms of a proposed biosynthetic pathway involving 18-hydroxylation of cortisol during a second passage through the adrenal gland.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0300-0664
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
23
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
579-86
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|
pubmed:dateRevised |
2006-11-15
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|
pubmed:meshHeading |
pubmed-meshheading:3002670-Adrenal Glands,
pubmed-meshheading:3002670-Adrenocorticotropic Hormone,
pubmed-meshheading:3002670-Aldosterone,
pubmed-meshheading:3002670-Angiotensin II,
pubmed-meshheading:3002670-Circadian Rhythm,
pubmed-meshheading:3002670-Dexamethasone,
pubmed-meshheading:3002670-Humans,
pubmed-meshheading:3002670-Hydrocortisone,
pubmed-meshheading:3002670-Hyperaldosteronism,
pubmed-meshheading:3002670-Male,
pubmed-meshheading:3002670-Radioimmunoassay,
pubmed-meshheading:3002670-Sodium
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|
pubmed:year |
1985
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|
pubmed:articleTitle |
Factors affecting the secretion of 18-hydroxycortisol, a novel steroid of relevance to Conn's syndrome.
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|
pubmed:publicationType |
Journal Article
|
