Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1986-1-24
pubmed:abstractText
The effect of tunicamycin, which inhibits N-linked glycosylation, on the replication of Epstein-Barr virus was examined. Tunicamycin markedly reduced the yield of virus from producing cells. At concentrations of 1 to 2 micrograms of tunicamycin per ml, there was a buildup of intracellular virus in P3HR1-Cl13 cells but not in MCUV5 cells; at a concentration of 5 micrograms of tunicamycin per ml in P3HR1-Cl13 cells, viral DNA synthesis was inhibited as well. Viral glycoproteins lacking N-linked sugars were apparently inserted into the cell membrane, and the small amount of virus made in the presence of drug was able to bind specifically to its receptor on B cells. However, the ability of the virus to induce immunoglobulin secretion by fresh human lymphocytes was impaired. This implies a role for viral glycoproteins in the penetration as well as the attachment of virus.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-14086209, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-221669, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-224538, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-2981343, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-4174339, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-4850204, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-503860, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-5432063, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-6087149, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-6172392, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-6177865, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-6180176, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-6184015, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-6246250, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-6248876, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-6248879, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-6250466, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-6254073, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-6256764, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-6276755, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-6283120, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-6289637, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-6292496, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-6296282, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-6301148, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-6302318, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-6305014, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-6315853, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-6319581, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-6319741, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-6320532, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-6324457, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-6337215, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-637870, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-791682, http://linkedlifedata.com/resource/pubmed/commentcorrection/3001337-881736
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
117-23
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
Modification of Epstein-Barr virus replication by tunicamycin.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.