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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1986-1-29
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pubmed:databankReference |
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pubmed:abstractText |
Structural analysis of a phage lambda Charon 4A clone carrying one of the human nuclear mitochondrial(mut)-DNA-like sequences revealed that a KpnI-family member (KpnI 5.5-kb DNA) is inserted within this sequence. The inserted KpnI 5.5-kb DNA contains several possible polyadenylation signal sequences followed by an A-rich sequence at its 3' end and is flanked by perfect 13-bp direct repeats of the duplicated mtDNA-like sequences. These structures strongly suggest that the KpnI 5.5-kb DNA is a mobile element. Comparison of the 5' terminal sequences of the KpnI 5.5-kb DNA and four other long KpnI-family DNAs so far examined, using the predicted general promoter sequence for eukaryotic tRNAs, indicates that they contain the consensus sequences for the split internal RNA polymerase III control region.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0378-1119
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
281-8
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pubmed:dateRevised |
2008-8-29
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pubmed:meshHeading |
pubmed-meshheading:3000880-Base Sequence,
pubmed-meshheading:3000880-Cell Nucleus,
pubmed-meshheading:3000880-Cloning, Molecular,
pubmed-meshheading:3000880-DNA, Mitochondrial,
pubmed-meshheading:3000880-DNA Restriction Enzymes,
pubmed-meshheading:3000880-DNA Transposable Elements,
pubmed-meshheading:3000880-Deoxyribonucleases, Type II Site-Specific,
pubmed-meshheading:3000880-Female,
pubmed-meshheading:3000880-Genes,
pubmed-meshheading:3000880-Humans,
pubmed-meshheading:3000880-Nucleic Acid Hybridization,
pubmed-meshheading:3000880-Placenta,
pubmed-meshheading:3000880-Plasmids,
pubmed-meshheading:3000880-Pregnancy,
pubmed-meshheading:3000880-Repetitive Sequences, Nucleic Acid
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pubmed:year |
1985
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pubmed:articleTitle |
Insertion of a long KpnI family member within a mitochondrial-DNA-like sequence present in the human nuclear genome.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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