Linked Life Data

2998887

Source:http://linkedlifedata.com/resource/pubmed/id/2998887

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
1986-1-21
pubmed:abstractText
The control of tension is examined in cardiac Purkinje fibers. We show, in accordance with earlier results (14, 15), that tension produced by this preparation is a steep power function of intracellular sodium. With the aid of ryanodine, a pharmacological agent that blocks spontaneous and spatially asynchronous calcium release from the sarcoplasmic reticulum (SR), we investigate the influence that such calcium fluctuations have on tension. We find that even when we control for alterations of intracellular pH, the presence of such fluctuations reduces the dependence of tension on intracellular sodium. We present a simple model that can explain how the presence of oscillations of intracellular calcium leads to a reduction of the slope of the tension-calcium relationship. We show, furthermore, that when the oscillations are spatially asynchronous, this reduction of slope is even greater. The modeling takes account of the known relationships between tension and calcium and tension and sarcomere length. We conclude that the effect of ryanodine to steepen the tension-sodium relationship can be explained by ryanodine's blocking calcium release from the SR, thereby abolishing oscillations of intracellular calcium.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0014-9446
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2964-9
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Ryanodine block of calcium oscillations in heart muscle and the sodium-tension relationship.
pubmed:publicationType
Journal Article, In Vitro