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rdf:type |
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lifeskim:mentions |
|
|
pubmed:issue |
2
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pubmed:dateCreated |
1985-12-30
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pubmed:abstractText |
Griseolic acid inhibited cAMP phosphodiesterase (PDE) at low concentrations, the I50 being of the order of 0.01-0.1 microM. Administration of griseolic acid to rats increased the cAMP level in liver and plasma several-fold. It increased glycogen degradation in mouse liver and stimulated lipolysis in isolated rat fat cells. Griseolic acid did not block the adenosine-elicited accumulation of cAMP in guinea pig brain slices. It had no effect on cAMP-dependent protein kinase from rat liver nor on the adenyl cyclase from rat brain.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0014-5793
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
18
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pubmed:volume |
192
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
179-83
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2998865-3',5'-Cyclic-AMP Phosphodiesterases,
pubmed-meshheading:2998865-Adenosine,
pubmed-meshheading:2998865-Adipose Tissue,
pubmed-meshheading:2998865-Animals,
pubmed-meshheading:2998865-Blood Glucose,
pubmed-meshheading:2998865-Brain,
pubmed-meshheading:2998865-Cerebral Cortex,
pubmed-meshheading:2998865-Cricetinae,
pubmed-meshheading:2998865-Cyclic AMP,
pubmed-meshheading:2998865-Cyclic GMP,
pubmed-meshheading:2998865-Guinea Pigs,
pubmed-meshheading:2998865-Kinetics,
pubmed-meshheading:2998865-Lipolysis,
pubmed-meshheading:2998865-Liver,
pubmed-meshheading:2998865-Liver Glycogen,
pubmed-meshheading:2998865-Male,
pubmed-meshheading:2998865-Mice,
pubmed-meshheading:2998865-Mice, Inbred Strains,
pubmed-meshheading:2998865-Rats,
pubmed-meshheading:2998865-Rats, Inbred Strains
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pubmed:year |
1985
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pubmed:articleTitle |
Biological properties of griseolic acid, a cyclic AMP phosphodiesterase inhibitor with an adenine group.
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pubmed:publicationType |
Journal Article,
In Vitro
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