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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1985-12-2
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pubmed:databankReference | |
pubmed:abstractText |
We have examined the coding capability and expression of the Drosophila homolog of the vertebrate proto-oncogene c-src. Sequence analysis of a cDNA clone representing the Drosophila c-src locus suggests that the gene encodes a 62 kd protein that is remarkably similar to the protein product of chicken c-src. The Drosophila c-src locus is transcribed into three mRNAs that are each regulated independently during development. Drosophila c-src RNA is abundant in embryos and pupae but rare in larvae and adults. In situ hybridization reveals that after the first 8 hr of development, c-src RNA accumulates almost exclusively in neural tissues such as the brain, ventral nerve chord, and eye-antennal discs, and in differentiating smooth muscle. We conclude that c-src may not be a mitotic signal but instead may play a role in the development of neural tissue and smooth muscle.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
|
pubmed:issn |
0092-8674
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
831-40
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:2996778-Amino Acid Sequence,
pubmed-meshheading:2996778-Animals,
pubmed-meshheading:2996778-Base Sequence,
pubmed-meshheading:2996778-Cloning, Molecular,
pubmed-meshheading:2996778-DNA Restriction Enzymes,
pubmed-meshheading:2996778-Drosophila,
pubmed-meshheading:2996778-Drosophila Proteins,
pubmed-meshheading:2996778-Genes,
pubmed-meshheading:2996778-Larva,
pubmed-meshheading:2996778-Nucleic Acid Hybridization,
pubmed-meshheading:2996778-Protein-Tyrosine Kinases,
pubmed-meshheading:2996778-Proto-Oncogene Proteins,
pubmed-meshheading:2996778-Proto-Oncogenes,
pubmed-meshheading:2996778-Pupa,
pubmed-meshheading:2996778-Sequence Homology, Nucleic Acid,
pubmed-meshheading:2996778-Transcription, Genetic
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pubmed:year |
1985
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pubmed:articleTitle |
The nucleotide sequence and the tissue-specific expression of Drosophila c-src.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|