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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1985-11-21
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pubmed:abstractText |
The phosphonomethyl analogue of 3-phosphoglycerate (2-hydroxy-4-phosphonobutanoate) is a potent competitive inhibitor of cofactor-dependent phosphoglycerate mutase from yeast and of cofactor-independent phosphoglycerate mutase from wheat germ. For the yeast enzyme Ki is 1.3 mM (Km for substrate is 0.71 mM); for the wheatgerm enzyme Ki is 18 mM (Km for substrate is 0.86 mM). This analogue should be a useful tool for n.m.r. spectroscopic studies on the mechanism of action of the two mutases. The arsonomethyl analogue of 3-phosphoglycerate (4-arsono-2-hydroxybutanoate) was a relatively poor inhibitor.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2996505-13630886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2996505-13654334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2996505-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2996505-19039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2996505-196622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2996505-4377103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2996505-4377104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2996505-4463959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2996505-4463960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2996505-5062057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2996505-5168977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2996505-5636382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2996505-5690561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2996505-6115412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2996505-6243955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2996505-6255773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2996505-6288465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2996505-6615422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2996505-7247
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
230
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
535-42
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1985
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pubmed:articleTitle |
The phosphonomethyl analogue of 3-phosphoglycerate is a potent competitive inhibitor of phosphoglycerate mutases.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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