|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4726
|
|
pubmed:dateCreated |
1985-11-18
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
The gene encoding the human interleukin-2 (IL-2) receptor consists of 8 exons spanning more than 25 kilobases on chromosome 10. Exons 2 and 4 were derived from a gene duplication event and unexpectedly also are homologous to the recognition domain of human complement factor B. Alternative messenger RNA (mRNA) splicing may delete exon 4 sequences, resulting in a mRNA that does not encode a functional IL-2 receptor. Leukemic T cells infected with HTLV-I and normal activated T cells express IL-2 receptors with identical deduced protein sequences. Receptor gene transcription is initiated at two principal sites in normal activated T cells. Adult T cell leukemia cells infected with HTLV-I show activity at both of these sites, but also at a third transcription initiation site.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0036-8075
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
8
|
|
pubmed:volume |
230
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
633-9
|
|
pubmed:dateRevised |
2007-3-19
|
|
pubmed:meshHeading |
pubmed-meshheading:2996141-Amino Acid Sequence,
pubmed-meshheading:2996141-Base Sequence,
pubmed-meshheading:2996141-Cloning, Molecular,
pubmed-meshheading:2996141-Complement Factor B,
pubmed-meshheading:2996141-DNA,
pubmed-meshheading:2996141-DNA, Recombinant,
pubmed-meshheading:2996141-Deltaretrovirus,
pubmed-meshheading:2996141-Genes, MHC Class II,
pubmed-meshheading:2996141-Humans,
pubmed-meshheading:2996141-Peptide Chain Initiation, Translational,
pubmed-meshheading:2996141-RNA, Messenger,
pubmed-meshheading:2996141-Receptors, Immunologic,
pubmed-meshheading:2996141-Receptors, Interleukin-2,
pubmed-meshheading:2996141-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:2996141-Retroviridae Infections,
pubmed-meshheading:2996141-T-Lymphocytes,
pubmed-meshheading:2996141-Transcription, Genetic
|
|
pubmed:year |
1985
|
|
pubmed:articleTitle |
Structure of the human interleukin-2 receptor gene.
|
|
pubmed:publicationType |
Journal Article
|
