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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
1985-10-31
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pubmed:abstractText |
The location of cis-acting regulatory regions within the long terminal repeat (LTR) of the human T-cell leukemia virus type I (HTLV-1) was determined. The sequences present between nucleotides -350 and -55 (cap site +1) contain an enhancer element that is active in lymphoid and nonlymphoid cell lines. The sequences located near the "TATA" and RNA initiation sites contain a promoter, the activity of which can be augmented by homologous and heterologous enhancer elements. A region responsive to trans-acting transcription factors present in HTLV-I- and HTLV type II-infected cells is located between nucleotides -159 and +315. HTLV-I LTR deletion mutants respond in a similar manner both to the trans-acting factors present in infected cells and to the tat protein encoded by the x-lor region of the genome, thus providing further evidence that the tat protein mediates transcriptional trans-activation of the LTR in HTLV-infected cells.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-215915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-265521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-2981427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-2981431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-2983419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-2986109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-2991605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-301762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-307230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-4705382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6089114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6089350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6089351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6093110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6093363,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6095084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6097028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6261256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6269744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6272126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6292901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6294651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6294664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6296859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6297005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6304725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6307525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6308622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6313355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6316341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6319019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6319764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6330570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6330891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6330894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6358900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6409419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6412453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6604273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6960240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-6979048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2995968-922889
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6502-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2995968-Avian Sarcoma Viruses,
pubmed-meshheading:2995968-Cell Transformation, Viral,
pubmed-meshheading:2995968-Cloning, Molecular,
pubmed-meshheading:2995968-Deltaretrovirus,
pubmed-meshheading:2995968-Enhancer Elements, Genetic,
pubmed-meshheading:2995968-Gene Products, tat,
pubmed-meshheading:2995968-Genes, Regulator,
pubmed-meshheading:2995968-Genes, Synthetic,
pubmed-meshheading:2995968-Genes, Viral,
pubmed-meshheading:2995968-Plasmids,
pubmed-meshheading:2995968-Promoter Regions, Genetic,
pubmed-meshheading:2995968-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:2995968-Simian virus 40,
pubmed-meshheading:2995968-Transcription, Genetic,
pubmed-meshheading:2995968-Transcription Factors,
pubmed-meshheading:2995968-Virus Replication
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pubmed:year |
1985
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pubmed:articleTitle |
Location of cis-acting regulatory sequences in the human T-cell leukemia virus type I long terminal repeat.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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