Linked Life Data

2994350

Source:http://linkedlifedata.com/resource/pubmed/id/2994350

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-10-15
pubmed:abstractText
Tissue samples from the salivary gland, lung spleen, liver and kidney of Balb/c mice infected with murine cytomegalovirus (MCMV) contained infective MCMV and virus-specific antigens for 6-7 weeks following the infection. After the 8th week no infective virus could be detected in any organ and antigens were found only in the spleen and the mesangial cells of the renal glomerules. As a result of cyclophosphamide treatment applied in the 22nd-24th weeks, the latent viral infection was reactivated in nearly all animals, infective virus production started again in the organs, and lasted for about 3 weeks. During the subsequent latent period the virus was again reactivated by repeated cyclophosphamide treatment. The experimental alternation of the latent and reactivated phases of viral infection renders the model suitable for study of the mechanism and consequences of viral latency and reactivation in vivo.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0231-4622
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
39-47
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
In vivo model for the acute, latent and reactivated phases of cytomegalovirus infection.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't