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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1985-10-17
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pubmed:abstractText |
The distribution of beta-adrenoceptor subtypes in slide-mounted sections of guinea-pig kidney has been examined by the technique of in vitro labelling combined with autoradiography. Binding of (-)-[125I]-cyanopindolol (Cyp) to kidney sections equilibrated and dissociated slowly, was saturable and stereoselective with respect to the isomers of propranolol and pindolol. These characteristics were appropriate for binding to beta-adrenoceptors. Delineation of beta-adrenoceptor subtypes was achieved by use of betaxolol (beta 1-adrenoceptors) and ICI 118,551 (beta 2-adrenoceptors) and computer assisted curve fitting techniques. Both beta 1- and beta 2-adrenoceptors were present in the proportions 1:2. 3H-Ultrofilm images of (-)-[125I]-Cyp binding to guinea-pig kidney sections showed localized patches of binding in the cortex and concentrated binding in the outer stripe of the medulla. Cortical receptors were of the beta 1 subtype and those associated with the outer stripe of the medulla were of the beta 2-adrenoceptor subtype. beta 1-Adrenoceptors were concentrated over glomeruli and beta 2-adrenoceptors over the straight portion of the proximal tubule.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-1175177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-1259022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-14284807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-17032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-217483,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-228806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-27279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-3519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-37256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-3977,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-4146284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-4155994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-43176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-4404297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-4996501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-507406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-5128289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-517668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-6101342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-6103908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-6107894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-6112660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-6119625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-6135130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-6250638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-6251307,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-6311583,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-6319079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-6349846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-7011200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-7377345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2992660-879322
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
341-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2992660-Animals,
pubmed-meshheading:2992660-Autoradiography,
pubmed-meshheading:2992660-Betaxolol,
pubmed-meshheading:2992660-Binding, Competitive,
pubmed-meshheading:2992660-Female,
pubmed-meshheading:2992660-Guinea Pigs,
pubmed-meshheading:2992660-Iodocyanopindolol,
pubmed-meshheading:2992660-Kidney,
pubmed-meshheading:2992660-Kidney Cortex,
pubmed-meshheading:2992660-Kidney Glomerulus,
pubmed-meshheading:2992660-Kidney Medulla,
pubmed-meshheading:2992660-Kidney Tubules, Proximal,
pubmed-meshheading:2992660-Male,
pubmed-meshheading:2992660-Pindolol,
pubmed-meshheading:2992660-Propanolamines,
pubmed-meshheading:2992660-Receptors, Adrenergic, beta,
pubmed-meshheading:2992660-Stereoisomerism,
pubmed-meshheading:2992660-Tissue Distribution
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pubmed:year |
1985
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pubmed:articleTitle |
Autoradiographic localization of beta-adrenoceptor subtypes in guinea-pig kidney.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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