| pubmed-article:2991744 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2991744 | lifeskim:mentions | umls-concept:C0043393 | lld:lifeskim |
| pubmed-article:2991744 | lifeskim:mentions | umls-concept:C0204727 | lld:lifeskim |
| pubmed-article:2991744 | lifeskim:mentions | umls-concept:C0205409 | lld:lifeskim |
| pubmed-article:2991744 | lifeskim:mentions | umls-concept:C0205160 | lld:lifeskim |
| pubmed-article:2991744 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:2991744 | lifeskim:mentions | umls-concept:C0079429 | lld:lifeskim |
| pubmed-article:2991744 | lifeskim:mentions | umls-concept:C1420391 | lld:lifeskim |
| pubmed-article:2991744 | lifeskim:mentions | umls-concept:C1704735 | lld:lifeskim |
| pubmed-article:2991744 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:2991744 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:2991744 | pubmed:dateCreated | 1985-9-4 | lld:pubmed |
| pubmed-article:2991744 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991744 | pubmed:abstractText | The his4-917 mutation of Saccharomyces cerevisiae results from the insertion of the Ty element Ty917 into the regulatory region of the HIS4 gene and renders the cell His-. The hist4-912 delta mutant, which carries a solo delta in the 5'-noncoding region of HIS4, is His+ at 37 degrees C but His- at 23 degrees C. Both these mutations interfere with HIS4 expression at the transcriptional level. The His- phenotype of both insertion mutations is suppressed by mutations at the SPT2 locus. The product of the wild-type SPT2 gene apparently represses HIS4 transcription in these mutant strains; this repression is relieved when the SPT2 gene is destroyed by mutation. The repression of transcription by SPT2 presumably results from an interaction between the SPT2+ gene product and Ty or delta sequences. In this paper, we report the cloning and DNA sequence analysis of the wild-type SPT2 gene and show that the gene is capable of encoding a protein of 333 amino acids in length. In addition, we show that a dominant mutation of the SPT2 gene results from the generation of an ochre codon which is presumed to lead to a shortened SPT2 gene product. | lld:pubmed |
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| pubmed-article:2991744 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2991744 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991744 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2991744 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2991744 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2991744 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2991744 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2991744 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:2991744 | pubmed:author | pubmed-author:SmithMM | lld:pubmed |
| pubmed-article:2991744 | pubmed:author | pubmed-author:BeardCC | lld:pubmed |
| pubmed-article:2991744 | pubmed:author | pubmed-author:RoederG SGS | lld:pubmed |
| pubmed-article:2991744 | pubmed:author | pubmed-author:KeranenSS | lld:pubmed |
| pubmed-article:2991744 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2991744 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:2991744 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2991744 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2991744 | pubmed:pagination | 1543-53 | lld:pubmed |
| pubmed-article:2991744 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:2991744 | pubmed:meshHeading | pubmed-meshheading:2991744-... | lld:pubmed |
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| pubmed-article:2991744 | pubmed:meshHeading | pubmed-meshheading:2991744-... | lld:pubmed |
| pubmed-article:2991744 | pubmed:meshHeading | pubmed-meshheading:2991744-... | lld:pubmed |
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| pubmed-article:2991744 | pubmed:meshHeading | pubmed-meshheading:2991744-... | lld:pubmed |
| pubmed-article:2991744 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:2991744 | pubmed:articleTitle | Isolation and characterization of the SPT2 gene, a negative regulator of Ty-controlled yeast gene expression. | lld:pubmed |
| pubmed-article:2991744 | pubmed:publicationType | Journal Article | lld:pubmed |
