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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1985-9-11
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pubmed:abstractText |
In 22 patients with malignancies, treated with high-dose chemoradiotherapy and autologous bone marrow transplantation (BMT), peripheral blood T cell subsets and functions were studied. In ten cytomegalovirus (CMV)-negative patients, CD4+ and CD8+ T cells (representing T cells of the helper/inducer phenotype and T cells of the suppressor/cytotoxic phenotype, respectively), recovered slowly and simultaneously. In 12 CMV-positive patients, however, CD8+ T cells recovered more rapidly than CD4+ T cells and rose to increased counts. No T cells with an immature phenotype (CD1+, OKT6+) were observed. Lymphocyte stimulation by herpes simplex virus infected fibroblasts (and by CMV-infected fibroblasts in CMV-positive patients) in contrast remained high and even increased after BMT in both groups. These data indicate that T cell recovery after autologous BMT is mainly due to proliferation of mature T cells present in the BM graft and not to generation of new T cells from T cell precursors.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0006-4971
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
428-31
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2990611-Antibodies, Viral,
pubmed-meshheading:2990611-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:2990611-Bone Marrow,
pubmed-meshheading:2990611-Bone Marrow Transplantation,
pubmed-meshheading:2990611-Cell Division,
pubmed-meshheading:2990611-Cells, Cultured,
pubmed-meshheading:2990611-Cytomegalovirus,
pubmed-meshheading:2990611-Cytomegalovirus Infections,
pubmed-meshheading:2990611-Follow-Up Studies,
pubmed-meshheading:2990611-Humans,
pubmed-meshheading:2990611-Lymphocyte Activation,
pubmed-meshheading:2990611-Neoplasms,
pubmed-meshheading:2990611-Simplexvirus,
pubmed-meshheading:2990611-T-Lymphocytes,
pubmed-meshheading:2990611-Whole-Body Irradiation
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pubmed:year |
1985
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pubmed:articleTitle |
Recovery of T cell subsets after autologous bone marrow transplantation is mainly due to proliferation of mature T cells in the graft.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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