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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
2
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pubmed:dateCreated |
1985-7-29
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pubmed:abstractText |
Deoxycholate promotes phospholipase C degradation of endogenous phosphatidyl[3H]inositol (Pl), phosphatidyl[3H]inositol monophosphate (PIP) and phosphatidyl[3H]inositol bisphosphate (PIP2) in rat cornea and human platelets. Hydrolysis of phosphatidyl[3H]inositol significantly lags polyphospho[3H]inositide degradation. Concomitantly, formation of [3H]inositol monophosphate (IP1) lags behind [3H]inositol bisphosphate (IP2) and [3H]inositol trisphosphate (IP3) production. These results demonstrate that rat cornea and human platelet phospholipase C cause a preferential hydrolysis of the endogenous polyphosphoinositides rather than phosphatidylinositol.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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|
pubmed:issn |
0006-291X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
14
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pubmed:volume |
129
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|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
411-6
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:2990455-Animals,
pubmed-meshheading:2990455-Blood Platelets,
pubmed-meshheading:2990455-Cornea,
pubmed-meshheading:2990455-Deoxycholic Acid,
pubmed-meshheading:2990455-Humans,
pubmed-meshheading:2990455-Hydrolysis,
pubmed-meshheading:2990455-Kinetics,
pubmed-meshheading:2990455-Male,
pubmed-meshheading:2990455-Phosphatidylinositol Phosphates,
pubmed-meshheading:2990455-Phosphatidylinositols,
pubmed-meshheading:2990455-Phospholipases,
pubmed-meshheading:2990455-Rats,
pubmed-meshheading:2990455-Type C Phospholipases
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|
pubmed:year |
1985
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|
pubmed:articleTitle |
Deoxycholate induces the preferential hydrolysis of polyphosphoinositides by human platelet and rat corneal phospholipase C.
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pubmed:publicationType |
Journal Article,
In Vitro
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