Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1985-8-14
|
| pubmed:abstractText |
Three acyclic guanosine analogs with similar structures, the (R) and (S) forms of 9-(3,4-dihydroxybutyl)guanine and 9-(4-hydroxybutyl)guanine, were compared for antiherpes activity in vivo and in vitro. The three guanosine analogs were viral thymidine kinase-dependent inhibitors of virus multiplication. In cell cultures, (S)-9-(3,4-dihydroxybutyl)guanine was the least active of these three drugs against a variety of herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) strains. This was also the case for a certain HSV-1 or HSV-2 strain in different cell lines. In cell cultures, (R)-9-(3,4-dihydroxybutyl)guanine and 9-(4-hydroxybutyl)guanine had similar antiherpes activities. However, in vivo in cutaneous HSV-1 infections in guinea pigs treated topically and in systemic HSV-2 infections in mice treated orally or intraperitoneally, only (R)-9-(3,4-dihydroxybutyl)guanine had a therapeutic effect. The extremely short half-life in plasma and the high clearance of 9-(4-hydroxybutyl)guanine as compared with those of (R)-9-(3,4-dihydroxybutyl)guanine probably made 9-(4-hydroxybutyl)guanine inefficacious when given intraperitoneally or orally to mice infected with herpesvirus. On the other hand, no kinetic differences between (R)-9-(3,4-dihydroxybutyl)guanine and 9-(4-hydroxybutyl)guanine were observed in penetration through guinea pig skin ex vivo, and no preferential metabolism of 9-(4-hydroxybutyl)guanine in skin was noted. We deduced that high thymidine levels in guinea pig skin preferentially antagonize the antiviral effect of 9-(4-hydroxybutyl) guanine in cutaneous HSV-1 infections.
|
| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2990325-204250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2990325-210500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2990325-6265398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2990325-6268019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2990325-6279738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2990325-6282214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2990325-6285736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2990325-6307131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2990325-6312878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2990325-6318659,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2990325-6329085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2990325-6436227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2990325-6703671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2990325-736794
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0066-4804
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
27
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
753-9
|
| pubmed:dateRevised |
2009-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:2990325-Acyclovir,
pubmed-meshheading:2990325-Animals,
pubmed-meshheading:2990325-Antiviral Agents,
pubmed-meshheading:2990325-Cell Line,
pubmed-meshheading:2990325-Cricetinae,
pubmed-meshheading:2990325-Diffusion,
pubmed-meshheading:2990325-Female,
pubmed-meshheading:2990325-Guinea Pigs,
pubmed-meshheading:2990325-Herpes Simplex,
pubmed-meshheading:2990325-Humans,
pubmed-meshheading:2990325-Kinetics,
pubmed-meshheading:2990325-Male,
pubmed-meshheading:2990325-Mice,
pubmed-meshheading:2990325-Simplexvirus,
pubmed-meshheading:2990325-Stereoisomerism
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Antiherpes effects and pharmacokinetic properties of 9-(4-hydroxybutyl) guanine and the (R) and (S) enantiomers of 9-(3,4-dihydroxybutyl)guanine.
|
| pubmed:publicationType |
Journal Article
|