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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1985-8-21
|
| pubmed:abstractText |
The avian leukemia sarcoma virus S13 transforms chicken and Japanese quail embryo fibroblasts and chicken erythroid cells in tissue culture. S13-induced erythroid transformation requires culture conditions suitable for the growth of normal erythroid precursors (H. Beug and M. J. Hayman (1984), Cell 36, 963-972). S13-transformed erythroid colonies contain a high percentage of cells that differentiate in absence of erythropoietin. S13 is defective in pol and env functions but can code for a complete set of gag proteins. Nonproducer cell clones transformed by S13 release a noninfectious viral particle containing gag but no functional env or pol proteins. They also synthesize a transformation-specific protein of 155,000 molecular weight. This protein reacts with antibody to viral envelope glycoproteins and appears to represent onc as well as env sequences. The 155,000-molecular weight env-linked protein does not cross react immunologically with an antiserum against the v-erb A and v-erb B gene products.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0042-6822
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
145
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
141-53
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2990096-Alpharetrovirus,
pubmed-meshheading:2990096-Animals,
pubmed-meshheading:2990096-Antigens, Polyomavirus Transforming,
pubmed-meshheading:2990096-Antigens, Viral, Tumor,
pubmed-meshheading:2990096-Bone Marrow Cells,
pubmed-meshheading:2990096-Cell Transformation, Neoplastic,
pubmed-meshheading:2990096-Cell Transformation, Viral,
pubmed-meshheading:2990096-Cells, Cultured,
pubmed-meshheading:2990096-Chickens,
pubmed-meshheading:2990096-Coturnix,
pubmed-meshheading:2990096-Defective Viruses,
pubmed-meshheading:2990096-Erythroblasts,
pubmed-meshheading:2990096-Erythropoiesis,
pubmed-meshheading:2990096-Fibroblasts,
pubmed-meshheading:2990096-Helper Viruses,
pubmed-meshheading:2990096-Oncogenes,
pubmed-meshheading:2990096-Viral Proteins,
pubmed-meshheading:2990096-Virus Replication
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
S13, a rapidly oncogenic replication-defective avian retrovirus.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|