| pubmed-article:2988790 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2988790 | lifeskim:mentions | umls-concept:C0042776 | lld:lifeskim |
| pubmed-article:2988790 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:2988790 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:2988790 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:2988790 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:2988790 | lifeskim:mentions | umls-concept:C0450429 | lld:lifeskim |
| pubmed-article:2988790 | lifeskim:mentions | umls-concept:C0162326 | lld:lifeskim |
| pubmed-article:2988790 | lifeskim:mentions | umls-concept:C0023978 | lld:lifeskim |
| pubmed-article:2988790 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:2988790 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:2988790 | pubmed:dateCreated | 1985-7-31 | lld:pubmed |
| pubmed-article:2988790 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2988790 | pubmed:abstractText | The location of cis-acting regulatory sequences within the long terminal repeat (LTR) of the human T cell lymphotropic virus type III (HTLV-III/LAV) was determined. An enhancer element capable of increasing the rate of transcription from a heterologous promoter, irrespective of distance and orientation, is located between nucleotides -137 and -17 (cap site +1). The promoter sequences present near the TATA box respond to heterologous enhancers. The sequences present between nucleotides -17 and +80 are responsive to HTLV-III-associated trans-acting regulatory factors. Activation of these sequences by the viral regulatory factors requires the presence of a functional enhancer. The enhancer requirement is nonspecific, as the enhancer sequences of RSV, HTLV-I, and SV40 can functionally replace the HTLV-III enhancer. These findings define a new type of regulatory element, provide insight into the mechanisms that regulate HTLV-III gene expression, and may help to explain the effects of this virus on infected cells. | lld:pubmed |
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| pubmed-article:2988790 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2988790 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2988790 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2988790 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2988790 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:2988790 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:2988790 | pubmed:author | pubmed-author:HaseltineW... | lld:pubmed |
| pubmed-article:2988790 | pubmed:author | pubmed-author:RosenC ACA | lld:pubmed |
| pubmed-article:2988790 | pubmed:author | pubmed-author:SodroskiJ GJG | lld:pubmed |
| pubmed-article:2988790 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2988790 | pubmed:volume | 41 | lld:pubmed |
| pubmed-article:2988790 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2988790 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2988790 | pubmed:pagination | 813-23 | lld:pubmed |
| pubmed-article:2988790 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:2988790 | pubmed:year | 1985 | lld:pubmed |
| pubmed-article:2988790 | pubmed:articleTitle | The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat. | lld:pubmed |
| pubmed-article:2988790 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2988790 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2988790 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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