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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6483
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pubmed:dateCreated |
1985-7-31
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pubmed:commentsCorrections |
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pubmed:keyword |
http://linkedlifedata.com/resource/pubmed/keyword/Acquired Immunodeficiency Syndrome,
http://linkedlifedata.com/resource/pubmed/keyword/Biology,
http://linkedlifedata.com/resource/pubmed/keyword/Developed Countries,
http://linkedlifedata.com/resource/pubmed/keyword/Diseases,
http://linkedlifedata.com/resource/pubmed/keyword/Europe,
http://linkedlifedata.com/resource/pubmed/keyword/Examinations And Diagnoses,
http://linkedlifedata.com/resource/pubmed/keyword/Hematological Effects,
http://linkedlifedata.com/resource/pubmed/keyword/Hemic System,
http://linkedlifedata.com/resource/pubmed/keyword/Hiv Infections,
http://linkedlifedata.com/resource/pubmed/keyword/Laboratory Examinations And Diagnoses,
http://linkedlifedata.com/resource/pubmed/keyword/Longitudinal Studies,
http://linkedlifedata.com/resource/pubmed/keyword/Northern Europe,
http://linkedlifedata.com/resource/pubmed/keyword/Physiology,
http://linkedlifedata.com/resource/pubmed/keyword/Research Methodology,
http://linkedlifedata.com/resource/pubmed/keyword/Research Report,
http://linkedlifedata.com/resource/pubmed/keyword/Studies,
http://linkedlifedata.com/resource/pubmed/keyword/United Kingdom,
http://linkedlifedata.com/resource/pubmed/keyword/Viral Diseases
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0267-0623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
290
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1705-6
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pubmed:dateRevised |
2009-11-18
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pubmed:otherAbstract |
PIP: Patients with hemophilia are at a risk for the acquired immuno-deficiency syndrome (AIDS). As part of a surveillance program on AIDS, a group of patients with hemophilia was studied for clinical and immunological features associated with the syndrome. 30 patients in England who had received factor VIII treatment within 5 years were studied. 29 (male) had hemophilia A, and 1 female heterozygote had been treated for postoperative bleeding. 1 man had been tattooed over 10 years previously. No other risk factors for AIDS were present. 5 patients had recently developed splenomegaly or lymphadenopathy, and 1 of these also had mild thrombocytopenia. No opportunistic infection or unexplained loss of weight was noted. A basal cell carcinoma of the face in a 59-year old was recorded. 20 patients had detectable HTLV-III antibodies at the most recent date of testing. After 1981 approximately 15% of the subjects seroconverted each year until 1984. Most of the seropositive patients had had large amounts of factor VIII treatment, predominantly commercial concentrate from the US. 4 patients who seroconverted during 1984 had had little treatment, including a man who had used only 3250 units during 1983 from the same batch of commercial concentrate. 5 patients had used only products from the National Health Service over 5 years, and all were seronegative. The results failed to identify features that might help distinguish between self limiting HTLV-III infection and leading to AIDS or a carrier state.
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pubmed:meshHeading |
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pubmed:year |
1985
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pubmed:articleTitle |
Seroconversion of human T cell lymphotrophic virus III (HTLV-III) in patients with haemophilia: a longitudinal study.
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pubmed:publicationType |
Journal Article
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