Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1985-6-25
pubmed:abstractText
Vaccinia virus mutants were obtained in high frequency from mouse Friend erythroleukemia (FEL) cells persistently infected with this virus, which contains a large (122-MDa) DNA. During long-term cell passages viral particles with deletions of the DNA are generated in FEL cells. These mutants have a major 8-MDa deletion starting between 2.2 and 3.2 MDa from the left terminus of the viral genome. More than half of the left end terminal repetition is deleted. These mutants have reduced infectivity compared to wild-type virus. The ease with which vaccinia virus mutants are obtained in FEL cells should provide a suitable system for generating mutants with other poxvirus and permit study of the genetic basis of virulence for this group of viruses.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-14036977, http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-197263, http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-509515, http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-521806, http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-6093123, http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-6183821, http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-6245500, http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-6250716, http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-6256085, http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-6259807, http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-6262520, http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-6262819, http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-6270348, http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-6275095, http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-6277506, http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-6286993, http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-6288254, http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-6289324, http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-6296831, http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-6324465, http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-6445508, http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-6452531, http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-6582506, http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-664234, http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-6702105, http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-6747602, http://linkedlifedata.com/resource/pubmed/commentcorrection/2987924-6956893
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
82
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3365-9
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Generation of a dominant 8-MDa deletion at the left terminus of vaccinia virus DNA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.