Linked Life Data

2987741

Source:http://linkedlifedata.com/resource/pubmed/id/2987741

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4-6
pubmed:dateCreated
1985-7-9
pubmed:abstractText
Immunocytochemical and receptor autoradiographic techniques have been utilized to examine the postnatal development of opioid peptides and receptors. The pattern of met-enkephalin-like immunoreactivity was very similar at birth to the adult, increasing only in intensity throughout postnatal development. In contrast, beta-endorphin-like immunoreactivity (BLI) in neonate was strikingly different from that of adult. In particular, cells and fibers were observed in germinal zones, structures present only in the neonate. The distribution of dynorphin-B-like immunoreactivity at birth was intermediate in its similarity to that of adult. Certain terminal fields were present, others developed postnatally, and others disappeared with age. In parallel studies, autoradiographic maps of mu, delta and kappa opioid receptor subtypes were generated to determine whether any correspondences existed between the developmental distribution of opioids and their receptors. Although significant overlap existed, no simple one-to-one relationship was observed. The differential localization of peptides and receptors in neonatal and adult brain suggests that opioids may subserve distinct functions in the neonate. In particular, the presence of BLI in the germinal zones, where postnatal neurogenesis occurs, implicates opioid systems in regulation of neuronal cell division.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0143-4179
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
469-72
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Postnatal development of opioid systems in rat brain.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.