Linked Life Data

2986519

Source:http://linkedlifedata.com/resource/pubmed/id/2986519

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1985-5-24
pubmed:abstractText
The principal objective of this article is to present evidence for the numerical and biological importance of cell death in tumour growth and regression. Much of this death has the morphology of apoptosis, a process observed elsewhere in biology in a variety of circumstances. Recent studies on the mechanism of apoptosis in non-neoplastic cells suggest that a relatively small number of specific intracellular changes are involved. Two of these are described: endonuclease activation within the nucleus, which coincides with the characteristic morphological changes there, and altered expression of surface carbohydrates, which may be responsible for the swift recognition and phagocytosis of apoptotic cells. It seems probable that similar events occur during the apoptosis of tumour cells. Further knowledge of the control of these endogenous mechanisms for effecting cell death could lead to powerful new means of controlling the growth of tumours.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
131-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
The biology of cell death in tumours.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't