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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1985-6-20
|
| pubmed:abstractText |
We have analyzed the transforming potential of two fos oncogene products in nonestablished cultures of mouse connective tissue cells: p55fos of FBJ-MuSV and p75gag-fos of FBR-MuSV. Although both proteins induced morphological transformation and colony formation at low cell density in a G418 resistance selection assay, p75gag-fos exhibited more pronounced transforming potential than p55fos. In addition, p75gag-fos-transformed cells overcame crisis with a high probability and were tumorigenic in syngenic mice. These properties of the FBR-MuSV appear to be linked to structural alterations in the p75gag-fos oncogene product. Polyoma virus large T protein complemented the transforming potential of fos, in that it not only increased the probability of establishment of fos-transformed cells but also enhanced fos-induced morphological transformation. Our results suggest that different oncogenes affect morphological transformation, low cell density growth, establishment, and tumorigenicity to various degrees.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0092-8674
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
41
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
629-37
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2985286-Animals,
pubmed-meshheading:2985286-Antigens, Polyomavirus Transforming,
pubmed-meshheading:2985286-Antigens, Viral, Tumor,
pubmed-meshheading:2985286-Cell Count,
pubmed-meshheading:2985286-Cell Line,
pubmed-meshheading:2985286-Cell Survival,
pubmed-meshheading:2985286-Cell Transformation, Neoplastic,
pubmed-meshheading:2985286-Cell Transformation, Viral,
pubmed-meshheading:2985286-Cells, Cultured,
pubmed-meshheading:2985286-Clone Cells,
pubmed-meshheading:2985286-Connective Tissue Cells,
pubmed-meshheading:2985286-Fibroblasts,
pubmed-meshheading:2985286-Genes, Viral,
pubmed-meshheading:2985286-Mice,
pubmed-meshheading:2985286-Oncogenes,
pubmed-meshheading:2985286-Osteosarcoma,
pubmed-meshheading:2985286-Phenotype,
pubmed-meshheading:2985286-Sarcoma Viruses, Murine,
pubmed-meshheading:2985286-Transfection,
pubmed-meshheading:2985286-Viral Proteins
|
| pubmed:year |
1985
|
| pubmed:articleTitle |
Extended life span and tumorigenicity of nonestablished mouse connective tissue cells transformed by the fos oncogene of FBR-MuSV.
|
| pubmed:publicationType |
Journal Article
|