Linked Life Data

2982503

Source:http://linkedlifedata.com/resource/pubmed/id/2982503

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1985-4-24
pubmed:abstractText
Using a transient expression assay in HeLa cells, we show that products from the adenovirus-5 E1a transcription unit repress transcription from the SV40 early promoter. The repression is unrelated to T antigen autoregulation, occurs maximally with low concentrations of E1a expression plasmid, is exerted at the transcriptional level, and requires functional E1a protein. The 289 and 243 amino acid E1a proteins are equally effective at repressing transcription. Since only the 289 amino acid protein is efficient at activating transcription, we conclude that activation and repression are separate E1a functions. We discuss possible mechanisms for E1a repression and the relationship of repression to the function of E1a in cell immortalization and transformation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0092-8674
pubmed:author
pubmed:issnType
Print
pubmed:volume
40
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
705-16
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1985
pubmed:articleTitle
Adenovirus E1a proteins repress transcription from the SV40 early promoter.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't