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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1985-3-20
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pubmed:abstractText |
The spin state of liver microsomal cytochrome P-450 from obese mice and streptozotocin-diabetic mice and rats has been studied both by the temperature and the type I substrates-induced spectral changes. The high spin cytochrome P-450 is significantly decreased in these animals. Moreover absolute spectra indicate that low spin cytochrome P-450 is stabilized in streptozotocin induced-diabetic animals. Thus the physiopathological state may modify the in vivo spin state of cytochrome P-450 and modifications of the microsomal fatty acid composition might contribute to these changes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
126
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
615-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2982381-Animals,
pubmed-meshheading:2982381-Cytochrome P-450 Enzyme System,
pubmed-meshheading:2982381-Diabetes Mellitus,
pubmed-meshheading:2982381-Diabetes Mellitus, Experimental,
pubmed-meshheading:2982381-Electron Spin Resonance Spectroscopy,
pubmed-meshheading:2982381-Fatty Acids,
pubmed-meshheading:2982381-Male,
pubmed-meshheading:2982381-Mice,
pubmed-meshheading:2982381-Mice, Inbred C57BL,
pubmed-meshheading:2982381-Mice, Obese,
pubmed-meshheading:2982381-Microsomes, Liver,
pubmed-meshheading:2982381-Obesity,
pubmed-meshheading:2982381-Rats,
pubmed-meshheading:2982381-Rats, Inbred Strains,
pubmed-meshheading:2982381-Spectrophotometry
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pubmed:year |
1985
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pubmed:articleTitle |
Spin state studies on cytochrome P-450 in liver microsomes from obese and diabetic animals.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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