Linked Life Data

2980555

Source:http://linkedlifedata.com/resource/pubmed/id/2980555

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1992-5-28
pubmed:abstractText
We studied the effect of metrizamide and iohexol on local cerebral glucose utilization (LCGU) using autoradiography. Metrizamide or iohexol was introduced into the subarachnoid space of rabbits and positioned over the right hemisphere for 3 or 6 hours. Using the unexposed (left) hemisphere as an internal control, we calculated relative changes in LCGU. In the three metrizamide-exposed animals the LCGU was decreased over the contrast media-exposed right temporoparietal cortex (L-R difference was positive). There was no significant changes in LCGU and no positive L-R difference after treatment with iohexol (three animals). We conclude that metrizamide does affect glucose metabolism in vivo, and this effect is dependent on localization of the contrast medium. The clinically safer drug, iohexol, in similar concentration and higher osmolality, did not decrease glucose metabolism.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0365-5954
pubmed:author
pubmed:issnType
Print
pubmed:volume
369
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
549-53
pubmed:dateRevised
2008-4-9
pubmed:meshHeading
pubmed:year
1986
pubmed:articleTitle
The effect of subarachnoid metrizamide and iohexol on cerebral glucose metabolism in vivo.
pubmed:affiliation
Department of Radiology, University of Rochester Medical Center, New York 14542.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't