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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1989-6-30
|
| pubmed:abstractText |
To study the clinical significance of abnormal myocardial perfusion in patients with hypertrophic cardiomyopathy (HCM), we performed a computerized washout analysis of digital subtraction coronary arteriograms in 28 patients with HCM and 16 control subjects. The contrast disappearance half-life (T1/2) was calculated from a time-density curve generated in the four sectors of the myocardium perfused by the left anterior descending coronary artery and the mean T1/2 was calculated by averaging T1/2 values for these four sectors. Patients with HCM demonstrated longer T1/2 in the ventricular septal region than control subjects. Thirteen (46%) of the patients with HCM presented abnormally longer mean T1/2 values, suggesting impaired myocardial perfusion. Family histories of HCM were more frequent in patients with abnormal mean T1/2 values (92% vs 47%; p less than 0.05). On the exercise stress test, patients with abnormal T1/2 values presented significantly lower exercise tolerance with more frequent exercise-induced ST segment depression (62% vs 13%; p less than 0.05). However, there were no significant differences between the two groups with regard to ventricular wall thickness, left ventricular end-diastolic pressure, or the severity of systolic narrowing of the coronary arteries. These findings suggest that 13 (46%) of the patients with HCM have impaired myocardial perfusion, which may be a manifestation of intramural coronary artery disease in addition to left ventricular hypertrophy, elevated left ventricular end-diastolic pressure, or systolic narrowing of the coronary arteries. Additionally, significant association of the prolonged T1/2 with a familial occurrence of HCM and depressed exercise tolerance with ST segment depression imply that impaired myocardial perfusion could be an important inherent pathophysiological state leading to myocardial ischemia during exercise.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0910-8327
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
4
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
170-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:2977783-Adolescent,
pubmed-meshheading:2977783-Adult,
pubmed-meshheading:2977783-Aged,
pubmed-meshheading:2977783-Cardiomegaly,
pubmed-meshheading:2977783-Cardiomyopathy, Hypertrophic,
pubmed-meshheading:2977783-Contrast Media,
pubmed-meshheading:2977783-Coronary Angiography,
pubmed-meshheading:2977783-Coronary Circulation,
pubmed-meshheading:2977783-Coronary Disease,
pubmed-meshheading:2977783-Electrocardiography,
pubmed-meshheading:2977783-Exercise Test,
pubmed-meshheading:2977783-Female,
pubmed-meshheading:2977783-Half-Life,
pubmed-meshheading:2977783-Humans,
pubmed-meshheading:2977783-Image Processing, Computer-Assisted,
pubmed-meshheading:2977783-Male,
pubmed-meshheading:2977783-Middle Aged,
pubmed-meshheading:2977783-Myocardium,
pubmed-meshheading:2977783-Subtraction Technique
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Impaired myocardial perfusion in patients with hypertrophic cardiomyopathy: assessment with digital subtraction coronary arteriography.
|
| pubmed:affiliation |
Third Department of Internal Medicine, Kurume University School of Medicine, Japan.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|