Linked Life Data

2976169

Source:http://linkedlifedata.com/resource/pubmed/id/2976169

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-4-4
pubmed:abstractText
Rats which received a liquid diet containing 6.5% (w/v) ethanol for three weeks became tolerant to the hypothermic effect of an acute dose of ethanol. Withdrawal of this diet was followed by loss of the tolerance within 3 days, and by an accompanying pattern of changes in levels of immunoreactive-ir-beta-endorphin in several brain regions. An initial decrease in levels on days 1 and 3 of withdrawal was followed by recovery to control levels on days 8 and 15. This pattern was found in the arcuate nucleus, amygdala, septum, periventricular thalamus and pre-optic periventricular hypothalamus (POPH), but was statistically significant only in the POPH. A different pattern of change in ir-beta-endorphin levels was found in the pituitary. The anterior lobe showed a significant depletion of ir-beta-endorphin levels before alcohol withdrawal, which recovered by day 8 of withdrawal. This depletion was probably not related to the loss of tolerance to ethanol but was a response to a perturbation of the hypothalamic-pituitary axis of hormonal control.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
933-9
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Effects of ethanol withdrawal on beta-endorphin levels in rat brain and pituitary.
pubmed:affiliation
Department of Pharmacology, University of Toronto, Canada.
pubmed:publicationType
Journal Article