Linked Life Data

2973043

Source:http://linkedlifedata.com/resource/pubmed/id/2973043

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
36
pubmed:dateCreated
1988-12-20
pubmed:abstractText
In a behavioural study, the effects of intravenous diclofenac in a range of doses were determined by measuring vocalization thresholds to paw pressure in normal and Freund's adjuvant-induced arthritic rats. In normal rats, 6 and 9 mg/kg diclofenac produced an increase in vocalization thresholds (mean threshold values were respectively 135.67 +/- 3.30 per cent and 157.41 +/- 4.62 per cent of the control at 30 min; n = 9 for each group), no effect resulting with 3 mg/kg. In arthritic rats, 3, 6 and 9 mg/kg diclofenac induced a clear analgesic effect (mean threshold values being 172.22 +/- 4.26 per cent, 201.76 +/- 4.76 per cent and 222.33 +/- 5.10 per cent respectively of the control at 25 min, n = 9 for each group), no effect being observed with 1.5 mg/kg. An electrophysiological study performed on arthritic rats considered the effect of 6 mg/kg diclofenac upon the neuronal ventrobasal thalamic responses induced by mode-rate stimulation of an inflamed joint. The responses were depressed by about 50 per cent, 20 minutes after the injection. These results show that diclofenac displays a direct effect on pain processing; this effect is more potent in arthritic rats than in normal rats.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0755-4982
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1841-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
[Analgesic action of sodium diclofenac: behavioral and electrophysiological study in normal and polyarthritic rats].
pubmed:affiliation
Unité de Recherches de Physiopharmacologie du système nerveux central de l'INSERM (U161), Paris.
pubmed:publicationType
Journal Article, English Abstract