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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1988-12-20
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pubmed:databankReference |
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pubmed:abstractText |
A human gene (LAR) that hybridizes to mouse leukocyte common antigen cDNA under relaxed hybridization conditions was isolated. The LAR gene is expressed in a broad range of cells, including T lymphocytes, kidney, and prostate cells. The structure of the protein encoded by the LAR gene was deduced by determining the nucleotide sequences of a 7.7-kb LAR cDNA. The putative LAR protein is composed of a 1,234 amino acid extracellular region, a 24 amino acid transmembrane segment, and a 623 amino acid cytoplasmic region. The cytoplasmic region contains two homologous domains that have extensive sequence similarity to the cytoplasmic region of the leukocyte common antigens. The NH2-terminal region of the extracellular segment of the LAR protein contains three tandem Ig-like domains and nine non-Ig-like domains. Among the known Ig-like proteins, the LAR protein has the highest degree of similarity to neural-cell adhesion molecule. The non-Ig-like domains of the LAR protein are also similar to the non-Ig-like domains of neural-cell adhesion molecule.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2972792-2824653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2972792-2944116,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2972792-2956090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2972792-2960772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2972792-3037546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2972792-3158393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2972792-3289571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2972792-3491628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2972792-3561488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2972792-3576199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2972792-3595563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2972792-3714490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2972792-6246368
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
168
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1523-30
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2972792-Amino Acid Sequence,
pubmed-meshheading:2972792-Animals,
pubmed-meshheading:2972792-Antigens, CD45,
pubmed-meshheading:2972792-Antigens, Differentiation,
pubmed-meshheading:2972792-Blotting, Northern,
pubmed-meshheading:2972792-Cytoplasm,
pubmed-meshheading:2972792-Genes,
pubmed-meshheading:2972792-Genes, Immunoglobulin,
pubmed-meshheading:2972792-Histocompatibility Antigens,
pubmed-meshheading:2972792-Humans,
pubmed-meshheading:2972792-Mice,
pubmed-meshheading:2972792-Molecular Sequence Data,
pubmed-meshheading:2972792-Multigene Family,
pubmed-meshheading:2972792-Restriction Mapping,
pubmed-meshheading:2972792-Sequence Homology, Nucleic Acid
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pubmed:year |
1988
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pubmed:articleTitle |
A new member of the immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen.
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pubmed:affiliation |
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, Massachusetts.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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