Linked Life Data

2972166

Source:http://linkedlifedata.com/resource/pubmed/id/2972166

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1988-11-8
pubmed:abstractText
The hypothalamic pituitary axis was studied in patients with an abnormal pattern of gonadotropin release during chronic treatment with LH-RH agonist. Two patients had PCOD and the third demonstrated the early luteinization phenomenon. Following a well-defined gonadotropin rise with initiation of LH-RH treatment, no further response was noted. Stabilization of the LH:FSH ratio in PCOD patients was noted after 4 weeks of treatment. Administration of both native LH-RH (100 micrograms) and intravenous pulsatile LH-RH did not evoke any rise in LH. In addition to the above LH-RH challenges, the positive feedback was examined by administration of estradiol benzoate (EB). The study demonstrated that, although the pituitary did not respond to any LH-RH challenge, it may still respond by a rise in LH following EB administration. Both functions of the hypothalamic pituitary axis should be examined in order to determine the state of medical hypophysectomy.
pubmed:language
eng
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:author
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-11
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:articleTitle
Abolishment of the positive feedback mechanism: a criterion for temporary medical hypophysectomy by LH-RH agonist.
pubmed:affiliation
Department of Obstetrics, Gynecology and Endocrinology, Chaim Sheba Medical Center, Sackler Medical School, Tel-Aviv University, Tel-Hashomer, Israel.
pubmed:publicationType
Journal Article