Linked Life Data

2972088

Source:http://linkedlifedata.com/resource/pubmed/id/2972088

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-11-23
pubmed:abstractText
Plasma samples from nineteen patients with well characterized lupus anticoagulants (LA) were evaluated using a series of test systems. An ELISA was used to determine if the plasmas contained antiphospholipid antibodies (APA); fifteen of nineteen LA plasmas contained APA, with five exhibiting IgG only, two exhibiting IgM, and eight plasmas containing both IgG and IgM. Anti-phosphatidyl serine (PS) was the predominant IgG specificity and all IgM APA-containing plasmas reacted with phosphatidyl inositol (PI). An ELISA was developed to determine if LA plasmas contained immunoglobulin which would associate with cultured human umbilical cord vein-derived endothelial cells (HUV); ten of nineteen plasmas contained endothelium associated immunoglobulin (EAI). There was significant concordance between the occurrence of EAI and IgM anti-PI. The occurrence of EAI or APA, either singly or in combination, did not correlate with a past history of thrombosis. Patient plasmas were incubated with HUV and examined for effects on HUV prostacyclin (PGI2) secretion; six plasmas significantly stimulated PGI2 secretion and one plasma was inhibitory. Finally, plasma levels of free and total antigenic protein S were determined by EID. Five plasmas contained significantly reduced levels of free antigenic protein S, and total antigenic protein S was reduced in ten plasmas. Patient histories were examined for evidence of thrombotic episodes; six patients had a history of either arterial or venous thrombosis, with five of these six patients having drug-induced LA. Thus, unlike previous studies, drug-induced LA were associated with thrombosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0049-3848
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
267-81
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:2972088-Adolescent, pubmed-meshheading:2972088-Adult, pubmed-meshheading:2972088-Aged, pubmed-meshheading:2972088-Aged, 80 and over, pubmed-meshheading:2972088-Autoantibodies, pubmed-meshheading:2972088-Blood Coagulation Factors, pubmed-meshheading:2972088-Cells, Cultured, pubmed-meshheading:2972088-Endothelium, Vascular, pubmed-meshheading:2972088-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:2972088-Epoprostenol, pubmed-meshheading:2972088-Female, pubmed-meshheading:2972088-Glycoproteins, pubmed-meshheading:2972088-Humans, pubmed-meshheading:2972088-Immunoglobulin G, pubmed-meshheading:2972088-Immunoglobulin M, pubmed-meshheading:2972088-Lupus Coagulation Inhibitor, pubmed-meshheading:2972088-Male, pubmed-meshheading:2972088-Middle Aged, pubmed-meshheading:2972088-Phospholipids, pubmed-meshheading:2972088-Protein S
pubmed:year
1988
pubmed:articleTitle
Evaluation of lupus anticoagulants: antiphospholipid antibodies, endothelium associated immunoglobulin, endothelial prostacyclin secretion, and antigenic protein S levels.
pubmed:affiliation
Muncie Center for Medical Education, Indiana University School of Medicine.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't