Linked Life Data

2971711

Source:http://linkedlifedata.com/resource/pubmed/id/2971711

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-11-15
pubmed:abstractText
Progeny from benzo(a)pyrene (BP) exposed (150 micrograms/g body weight) primiparous mothers, injected during the second trimester of pregnancy, are severely compromised immunologically. In view of maternal-fetal associations, we studied, during pregnancy and postpartum, the quantitative and functional status of the maternal T cell population in the thymus and/or spleen. In the thymus, there is an exacerbated depression in the amounts of thymocytes, (theta +, Lyt 1+, Lyt 2+ cells) during pregnancy relative to the corn oil-injected controls, which is sustained postpartum. In the spleen, while there are inconsistencies in the level of theta + cells, The Lyt 1+ are depressed postpartum relative to virgins, but the Lyt 2+ are enhanced during pregnancy and postpartum, reaching levels greater than 700-fold of controls. In controls, while the number of Lyt 1+ cells was higher than BP-exposed mice or virgins during pregnancy, they virtually disappeared postpartum. A similar but reversed image is mirrored by the Lyt 2+ cells, i.e., they were virtually absent during pregnancy but increased postpartum. Splenic allogeneic and syngeneic mixed lymphocyte responses were subnormal. The data show that BP disrupts the maternal T cell repertoire, leading to an accumulation of Lyt 1-2+ cells, and suggest that splenic disruption may be due to changes in the differentiation potential of T precursor cells. These changes not only are most likely to affect maternal defenses, but also may have a direct bearing on the establishment of progeny immune status.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0892-3973
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
195-217
pubmed:dateRevised
2009-5-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Quantitative and functional change in T cells of primiparous mice following injection of benzo(a)pyrene at the second trimester of pregnancy.
pubmed:affiliation
Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, GA 30310-1495.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.