Linked Life Data

2971187

Source:http://linkedlifedata.com/resource/pubmed/id/2971187

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
pubmed:issue
28
pubmed:dateCreated
1988-10-21
pubmed:abstractText
RU 41740 is an immunomodulator of organic origin to be used preventively against recurrent respiratory infections in both adults and children. The immunological safety of the drug was first studied on NZB-NZW mice which spontaneously develop a disease resembling lupus erythematosus. The survival rate of these mice and the amounts of protein excreted in the urine were not modified by the compound. Clinically, RU 41740 was well tolerated by the adult mice and their offspring. Studies on immunological safety were also conducted in human adults and children. Compared with pre-treatment values, there were no pathological changes in blood count and differential, erythrocyte sedimentation rate, immunoglobulins E, A, M and G levels, apolipoproteins, haptoglobin, haemolytic complement, antinuclear factors, rheumatic serology and anti-red cell antibodies. In addition, the drug was well tolerated by atopic subjects.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0755-4982
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1458-60
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
[Immunotolerance of RU 41740].
pubmed:affiliation
Unité de Recherches sur la Pathologie autoimmune (INSERM U283), Hôpital Cochin, Paris.
pubmed:publicationType
Journal Article, Clinical Trial, English Abstract, Review