| pubmed-article:2969804 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2969804 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:2969804 | lifeskim:mentions | umls-concept:C0026249 | lld:lifeskim |
| pubmed-article:2969804 | lifeskim:mentions | umls-concept:C0049700 | lld:lifeskim |
| pubmed-article:2969804 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:2969804 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:2969804 | lifeskim:mentions | umls-concept:C0031584 | lld:lifeskim |
| pubmed-article:2969804 | lifeskim:mentions | umls-concept:C0060767 | lld:lifeskim |
| pubmed-article:2969804 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2969804 | pubmed:dateCreated | 1988-9-20 | lld:pubmed |
| pubmed-article:2969804 | pubmed:abstractText | The influence of tumour promoters and growth factors on glycolysis and on fructose-2,6-bisphosphate concentration was studied in isolated mouse spleen lymphocytes and in purified B-cells. The intracellular concentration of fructose 2,6-bisphosphate and the rate of lactate release were increased 2-3-fold in spleen lymphocytes exposed to active phorbol esters, mitogenic lectins, interleukin 4 or lipopolysaccharide. The maximal effect was observed after 1 h of exposure. In these cells hexose 6-phosphates increased 2-fold and 6-phosphofructo-2-kinase activity remained unchanged after treatment with phorbol 12,13-dibutyrate or with lectins. Exposure of B-cells to phorbol 12,13-dibutyrate, interleukin 4 or lipopolysaccharide increased the glycolytic flux and the concentration of fructose 2,6-bisphosphate without relation to their mitogenic activity. Lymphocytes and rat liver 6-phosphofructo-2-kinase were partially purified using the same procedure. The lymphocyte enzyme was not inhibited by sn-glycerol 3-phosphate in contrast to the potent inhibition observed in liver. Treatment of both enzymes with the catalytic subunit of the cyclic-AMP-dependent protein kinase failed to inactivate 6-phosphofructo-2-kinase from lymphocytes. These differences suggest that lymphocytes and liver contain different forms of this enzyme. | lld:pubmed |
| pubmed-article:2969804 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2969804 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2969804 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2969804 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2969804 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:2969804 | pubmed:issn | 0014-2956 | lld:pubmed |
| pubmed-article:2969804 | pubmed:author | pubmed-author:BoschCC | lld:pubmed |
| pubmed-article:2969804 | pubmed:author | pubmed-author:MarquetEE | lld:pubmed |
| pubmed-article:2969804 | pubmed:author | pubmed-author:MojenaMM | lld:pubmed |
| pubmed-article:2969804 | pubmed:author | pubmed-author:Diaz-GuerraJ... | lld:pubmed |
| pubmed-article:2969804 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2969804 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2969804 | pubmed:volume | 175 | lld:pubmed |
| pubmed-article:2969804 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2969804 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2969804 | pubmed:pagination | 317-23 | lld:pubmed |
| pubmed-article:2969804 | pubmed:dateRevised | 2007-7-23 | lld:pubmed |
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| pubmed-article:2969804 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:2969804 | pubmed:articleTitle | Phorbol 12,13-dibutyrate and mitogens increase fructose 2,6-bisphosphate in lymphocytes. Comparison of lymphocyte and rat-liver 6-phosphofructo-2-kinase. | lld:pubmed |
| pubmed-article:2969804 | pubmed:affiliation | Instituto de Bioquímica, Facultad de Farmacia, Madrid, Spain. | lld:pubmed |
| pubmed-article:2969804 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2969804 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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