Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1988-8-25
|
| pubmed:abstractText |
Middle-aged (18 month old) and old (24 month old) mice showed poorer retention of footshock active avoidance training (FAAT) than young mice (2 month old). Immediate post-training subcutaneous injection of dehydroepiandrosterone sulfate (DHEAS) improved retention of FAAT in middle-aged and old mice to the high levels observed in young mice. DHEAS, a major naturally occurring adrenal steroid that decreases in blood serum with age, could be rate-limiting in achievement of retention of learning.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0006-8993
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
10
|
| pubmed:volume |
448
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
178-81
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:2968829-Aging,
pubmed-meshheading:2968829-Animals,
pubmed-meshheading:2968829-Avoidance Learning,
pubmed-meshheading:2968829-Dehydroepiandrosterone,
pubmed-meshheading:2968829-Dehydroepiandrosterone Sulfate,
pubmed-meshheading:2968829-Male,
pubmed-meshheading:2968829-Memory,
pubmed-meshheading:2968829-Mice,
pubmed-meshheading:2968829-Mice, Inbred C57BL
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Dehydroepiandrosterone sulfate improves memory in aging mice.
|
| pubmed:affiliation |
Geriatric Research, Education and Clinical Center (GRECC), Veterans Administration Hospital, Sepulveda, CA 91343.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|